JuneCite as. In the elderly various syndromes are related to deficiency of the steroid hormones testosterone and oestradiol, i. In these conditions the measurement of circulating levels of these steroids plays an important diagnostic role. In epidemiological studies determination of the serum level of oestradiol is often used to assess its pathogenetic role in hormone-related conditions, including cancer of the breast, ovary, prostate and liver. At these decision levels commercial automated direct immunoassays for total testosterone, largely used in ruolo della prostata nel maschio laboratories, show sufficient diagnostic accuracy.
Free testosterone assays based on analogue displacement immunoassays are widely available, but their use is not recommended. Free testosterone levels can be measured accurately by equilibrium dialysis and ammonium sulphate precipitation or calculated from total testosterone, sex hormone binding globulin and albumin.
Direct automated immunoassays, available in clinical laboratories, are not considered valid tools for the measurement of low oestradiol levels, due to insufficient analytical sensitivity and specificity. The optimum assay for this measurement is chromatography associated with tandem mass spectrometry; however, this technique also needs standardization. Skip to main content.
Advertisement Hide. The diagnostic role of testosterone and oestradiol ruolo della prostata nel maschio the elderly. This is a preview of subscription content, log in to check access. Wang C, Niesclag E, Sverdloff R et al Investigation, treatment and monitoring of late-onset hypogonadism ruolo della prostata nel maschio males. Bhasin S, Zhang A, Coviello A et al The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders.
Platz EA Low testosterone and risk of premature death in older men: analytical and preanalytical issues in measuring circulating testosterone. Simon JA Estrogen replacement therapy: effects on the endogenous androgen milieu. Rosner W, Auchus RJ, Azziz Ruolo della prostata nel maschio et al Utility, limitations, and pitfalls in measuring testosterone: an endocrine society position statement. Ly LP, Handelsman DJ Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays.
Serum bioavailable testosterone: assayed or calculated? Vermeulen A Hormonal cut-offs ruolo della prostata nel maschio partial androgen deficiency: a survey of androgen assays. J Endocrinol Invest. Thaler M, Metzger J, Schreiegg A et al Immunoassay for sex hormone-binding globulin in undiluted serum is influenced by high-molecular-mass aggregates. Stanczyk FK, Jurow J, Hsing AW Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies.
Ouyang P, Vaidya D, Dobs A et al Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the multiethnic study of atherosclerosis. Van Geel TACM, Geusens PP, Winkens B et al Measures of bioavailable serum testosterone and estradiol and their relationship with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study.
Menopause — PubMed Google Scholar. Maria degli Angeli Pordenone Italy. Personalised recommendations. Cite article How to cite? ENW EndNote. Buy options.