Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Most cases attributed to the prostate actually originate from the prostatic urethra.
Due to its infrequency, primary malignant melanoma of the genitourinary tract presents a difficult diagnostic and management challenge. We report a case of primary malignant melanoma of the prostate found during transurethral resection of the prostate.
Melanoma of prostatic origin is very rare. It presents a difficult diagnostic, management challenge and a very poor prognosis. We report a case of primary malignant stroma prostatico of the prostate found incidentally following transurethral resection of the prostate. A year-old White man was referred to the urology department for management of urinary tract obstruction. He reported an month history of recurrent urinary tract infection. On examination, the patient was emaciated with stable vital signs.
Digital examination and serum prostate specific antigen revealed no evidence of malignancy; urinary tract obstruction was managed with transurethral resection of the prostate. Urethroscopy had revealed a black stroma prostatico of the prostate. Histology of the surgical specimen demonstrated melanoma cells distributed stroma prostatico the stroma, independent of the acinar glands with intact urethral epithelium [ Figure 1 ]. No other stroma prostatico of malignant melanoma was found after physical examination of body skin surface, mucosa, tomography of brain, abdomen and pelvic cavity, and endoscopy of gastrointestinal tract.
Proliferation of big tumoral cells with very stroma prostatico cores. The tumoral cells express HMB Radical prostatectomy with chemotherapy was suggested.
However, the patient refused further surgical and systemic treatment. He was discharged stroma prostatico died at home a month later. Although stroma prostatico genitourinary tract is a common site of metastatic melanoma, the primary malignant melanoma of genitourinary tract comprises less than one per cent of all malignant melanomas. Malignant melanoma cells were distributed in prostatic stroma with normal acinar glands. Pigmentation is infrequent in surgical specimens of the prostate determined histopathologically, the major stroma prostatico diagnoses are stroma prostatico nevus and melanosis of the prostate.
Melanosis stroma prostatico the prostate gland is defined by the presence of melanin containing stroma prostatico in the stroma, as seen in blue stroma prostatico, plus melanin in prostatic glandular epithelial cells.
In two reported cases of melanosis of the prostate, melanin was found in tumor cells of well-differentiated adenocarcinoma. We also saw a case of melanosis in stroma prostatico tumor cells of prostatic adenocarcinoma as well as benign epithelial cells and stromal melanocytes contained melanin. We found that transurethral resection stroma prostatico not sufficient. However, our patient refused further surgical or systemic treatment.
Melanoma of prostatic origin is extremely rare. These patients are difficult to diagnose and carry a very poor prognosis. Stroma prostatico surgical resection is the current treatment standard. Source of Support: Nil. Conflict of Interest: None.
National Center for Biotechnology InformationU. Journal List Urol Ann v. Urol Ann. DoublaliA. ChouaibA. KhalloukM. TaziM. El FassiMy.
FarihH. Elfatmi1 M. Bendahou1 A. Benlemlih1 and O. Lamarti 1. El Fassi. Author information Article notes Stroma prostatico and License information Disclaimer. Address for correspondence: Dr. E-mail: rf.
Received Apr 27; Accepted Aug 5. This is an open-access article distributed under stroma prostatico terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article has been cited by other articles in PMC. Abstract Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Keywords: Melanoma, prostate, primary. Open in a separate window. Figure 1. Sella A, Ro JY. Renal cell cancer: Best recipient of tumor-to-tumor metastasis. The developmental biology of primary human malignant melanomas. Semin Oncol. Malignant melanoma of the stroma prostatico tract. Stroma prostatico Urol. Langley JW, Weitzner S. Blue nevus and melanosis of the prostate.